Efektivitas SNEDDS Kombinasi Fraksi Etil Asetat Daun Cengkodok (Melasthoma malabathricum)-Antibiotik terhadap Bakteri Hasil Isolat dari Pasien Ulkus Diabetik
DOI:
https://doi.org/10.21776/ub.pji.2022.007.02.5Keywords:
Nanospray, SNEDDS, fraction of cengkodok leaves, antibiotic, and diabetic ulcerAbstract
Diabetic ulcer is a condition where there are neurological abnormalities and peripheral arterial
vascular disease that causes infection, ulceration, and/or damage to the deepest skin tissue on the feet
of people with diabetes mellitus (DM). The long duration of wound healing is due to the wrong use of
antibiotics for a long time, and bacteria tend to become resistant to antibiotics. Antimicrobial
compound fraction of cengkodok combined with gentamicin and ciprofloxacin antibiotics for
prevention and reduction of antibiotic resistance in the cause of diabetic ulcers. The drug preparation
is in the form of self nanoemulsifiying drug delivery system (SNEDDS), which is the optimum
combination of cengkodok leaf fraction with gentamicin and ciprofloxacin antibiotics. The use of
SNEDDS in this study is because the SNEDDS made from nanoemulsion formulations has small
particle size, large surface absorption, and good dispersion, so that it can be evenly dispersed on the
skin and penetrates the skin layer. This study aims to determine the effectiveness of the formulation
cengkodok leaf fraction with gentamicin and ciprofloxacin antibiotics against B. cereus and S. aureus
using the SNEDDS drug delivery system. The test uses the spotless diffusion method without using
paper discs. The results showed that the combination of cengkodok leaf fraction with gentamicin and
ciprofloxacin antibiotics had better activity against B. cereus and S. aureus than cengkodok leaf
fraction, gentamicin and ciprofloxacin only.
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