Pengaruh Kombinasi Matriks terhadap Karakter Tablet Metformin HCl Lepas Lambat Sistem Floating Effervescent

Abstract

The research aimed to prepare and evaluate of sustained release metformin HCl tablet with
floating system. The tablets were prepared by wet granulation using HPMC K4M and chitosan as matrixes
with proportions (w/w) 17.78%:4.44%; 14.44%:7.78%; 11.11%:11.11% ;7.78%;14.44%; 4.44%:17.78%.
The tablets were evaluated of weight variation, drug content, hardness, friability, and in vitro floating and
drug release studies. The dissolution study had been carried out for 6 hours using USP dissolution
apparatus II (paddle) in 900 ml HCl pH 3.0 media at 37±0.50C. All tablet formulas showed closed
similarity with the requirement physical tablet of United State Pharmacopea (USP) and Farmakope
Indonesia reference. The matrixes containing higher HPMC K4M, and lower chitosan showed floating lag
time decreased and duration time increased. Meanwhile, tablet disintegration was the lowest. The release
test showed that all formulas did not meet the requirements dissolution metformin HCl sustained release
tablet. The result of this study is sustained release tablet metformin HCl with matrixes HPMC K4M and
chitosan able to float, but it did not form sustained release.