Pengaruh Kombinasi Polimer PVP:EC dan HPMC:EC Terhadap Sediaan Transdermal Pada Karakteristik Patch yang Baik : Review

Authors

  • Nova Fuziyanti Universitas Garut

DOI:

https://doi.org/10.21776/ub.pji.2022.007.02.10

Keywords:

Transdermal, Kombinasi Polimer, Karakteristik

Abstract

Transdermal is a drug delivery system that is placed through the surface of the skin to release
the active substance in a certain dose into the bloodstream. The main constituent component in the
transdermal drug delivery system which has an effect on characteristics is polymer. One of the
developments in the transdermal route is the manufacture of patch preparations. Physically, a good
patch must be flexible, thin, smooth, homogeneous, have drying shrinkage and low moisture
absorption. So the aim of this review article was to determine the effect of polymer combinations on
transdermal preparations on good patch characteristics. The method used in this review article is a
literature review of various journals published online, with the category of national and international
journals. The results obtained 2 primary journals related to polymer combinations to transdermal
preparations, namely the combination of PVP: EC and HPMC: EC. The results of the review show that
the polymer combination can have an influence on the characteristics of the patch, including the fold
resistance test, weight uniformity test, thickness test, drying shrinkage test and moisture absorption
test.

References

Rahim F, Deviarny C, Yenti R, Ramdani P. Formulasi Sediaan Patch Transdermal dari Rimpang Rumput Teki (Cyperus rotundus L.) Untuk Pengobatan Nyeri Sendi Pada Tikus Putih Jantan. Scientia. 2016;6(1):1-6.

Ermawati DE, Prilantari U. Pengaruh Kombinasi Polimer Hidroksipropilmetilselulosa dan Natrium Karboksimetilselulosa terhadap Sifat Fisik Sediaan Matrix-based Patch Ibuprofen. 2019;02:109-119. doi:10.20961/jpscr.v4i2.34525

Suryani, Ode W, Musnina S, Anto AS. Optimasi Formula Matriks Patch Transdermal Nanopartikel Teofilin dengan Menggunakan Metode Simplex Lattice Design ( SLD ). 2015;3(1):26-32.

Ismail I, Ningsih S, Putrianti N. Formulasi, Karakteristik dan Uji Penetrasi In Vitro Patch Ekstrak Biji Kopi Robusta (Coffea Canephora ) Sebagai Sediaan Anti Selulit. 2015;2(3):1-60.

Ammar HO, Ghorab M, El-Nahhas SA, Kamel R. Polymeric matrix system for prolonged delivery of tramadol hydrochloride, part I: Physicochemical evaluation. AAPS PharmSciTech. 2009;10(1):7-20. doi:10.1208/s12249-008-9167-0

Arunachalam A, Karthikeyan M, Kumar DV, Prathap M, Sethuraman S, Ashutoshkumar S. Review Article Current Pharma Research Transdermal Drug Delivery System : A Review. Curr Pharma Res. 2010;1(1).

Rowe C R, Sheskey J P, Quinn E M. Handbook Of Pharmaceutical Excipients. Rev des Nouv Technol l’Information. 2015;E.28:262-265, 517-521, 592-593, 600-601.

Patel D, Chaudhary SA, Parmar B, Bhura N. THE PHARMA INNOVATION Transdermal Drug Delivery System: A Review. 2012;1(4). www.thepharmajournal.com.

Gavasane AJ. Synthetic Biodegradable Polymers Used in Controlled Drug Delivery System: An Overview. Clin Pharmacol Biopharm. 2014;3(2). doi:10.4172/2167-065x.1000121

Gaikwad KA. Transdermal Drug Delivery System: Formulation Aspects and Evaluation. Rev Artic. 2014;14(2):471-474. doi:10.1016/j.mpsur.2011.06.010

Prabhakar D, Sreekanth J, Jayaveera KN. Transdermal Drug Delivery Patches: a Review. J Drug Deliv Ther. 2013;3(4):213-221. doi:10.22270/jddt.v3i4.590

Digambar Mali A, Bathe R, Patil M. An Updated Review On Transdermal Drug Delivery System. Int J Adv Sci Res. 2015;1(06):244-254. doi:10.7439/ijasr

Fatmawaty A, Nisa M, Irmayani, Sunarti. Formulasi Patch Ekstrak Etanol Daun Murbei (Morus Alba L.) dengan Variasi Konsentrasi Polimer Polivinil Pirolidon dan Etil Selulosa. J Pharm Med Sci. 2017;2(1):17-20.

Arifin A, Iqbal M. Formulasi dan Uji Karakteristik Fisik Sediaan Patch Ekstrak Etanol Daun Kumis Kucing (Orthosiphon Stamineus). 2019;5(2):187-191.

Parivesh S, Sumeet D, Abhishek D. Design, Evaluation, Parameters and Marketed Products of transdermal patches: A Review. J Pharm Res. 2010;3(2):235-240.

Misnamayanti M, Sugihantoro H, Fauziyah B. Pengaruh Variasi Konsentrasi Propilen Glikol Sebagai Enhancer Terhadap Sediaan Transdermal Patch Ibuprofen In Vitro. J Islam Pharm. 2019;4(2):27-31. doi:10.18860/jip.v4i2.8029

Al Hanbali OA, Khan HMS, Sarfraz M, Arafat M, Ijaz S, Hameed A. Transdermal patches: Design and current approaches to painless drug delivery. Acta Pharm. 2019;69(2):197-215. doi:10.2478/acph-2019-0016

Patel NA, Patel NJ, Patel RP. Design and evaluation of transdermal drug delivery system for curcumin as an anti-inflammatory drug. Drug Dev Ind Pharm. 2009;35(2):234-242. doi:10.1080/03639040802266782

Purnama H, Mita SR. Review Artikel: Studi In-Vitro Ketoprofen Melalui Rute Transdermal. Farmaka. 2018;14(1):70-80.

Ameliana L, Nurahmanto D, Puspitasari KD. Optimasi Hidroksipropil Metilselulosa dan Carbopol terhadap Moisture Content dan Laju Pelepasan Patch Ibuprofen In Vitro (Optimization of Hydroxypropyl Methylcellulose and Carbopol for Moisture Content and Release Rate of Ibuprofen Patch In Vitro). Pustaka Kesehat. 2016;(Vol 4 No 2 (2016)):229-234. https://jurnal.unej.ac.id/index.php/JPK/article/view/3033.

Kandavilli S, Nair V, Panchagnula R. Polymers in transdermal drug delivery systems. Pharm Technol North Am. 2002;26(5):62-80. doi:10.5360/membrane.19.75

Hermanto FJ, Nurviana V. Evaluasi Sediaan Patch Daun Handeuleum (Graptophyllum griff L) Sebagai Penurun Panas. J Kesehat Bakti Tunas Husada J Ilmu-ilmu Keperawatan, Anal Kesehat dan Farm. 2019;19(2):209. doi:10.36465/jkbth.v19i2.499

Ameliana L, Nurahmanto D, Puspitasari KD. Optimasi Hidroksipropil Metilselulosa dan Carbopol terhadap Moisture Content dan Laju Pelepasan Patch Ibuprofen In Vitro. Pustaka Kesehat. 2016;(Vol 4 No 2 (2016)):229-234. https://jurnal.unej.ac.id/index.php/JPK/article/view/3033.

Arifin A, Marianti S. Evaluasi Karakteristik Fisik dan Uji Permeasi Pada Formula Patch Aspirin Menggunakan Kombinasi Etil Selulosa Dengan Polivinilpirolidon. J Sains dan Kesehat. 2019;2(1):40-49.

Nurahmanto D. Pengaruh Perbedaan Chemical Penetration Enhancer Pada Penetrasi Transdermal Patch Prometazin Hcl. 2016;2(2):208-217.

Downloads

Published

2022-06-30

Issue

Vol. 7 No. 2 (2022)

Section

Articles

License

Copyright (c) 2022 Pharmaceutical Journal of Indonesia Creative Commons Licence
This work is licensed under a Creative Commons Attribution 4.0 International License